Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1.

ABSTRACT: Cisplatin is a widely used, effective chemotherapy drug. However, its application is often limited by severe side effects, including testicular toxicity. Cisplatin-induced testicular damage is primarily driven by oxidative stress and inflammation. Ferroptosis has recently been identified to contribute to cisplatin-testicular toxicity. Morin hydrate (MH) is a naturally occurring flavonoid known for its powerful antioxidant, anti-inflammatory, and anti-apoptotic properties. The study was designed to evaluate the protective effects of MH against cisplatin-induced testicular toxicity in Wistar albino rats. Rats were given MH 50 mg/kg, p.o. daily for fourteen days, seven days before the injection of cisplatin 8 mg/kg. Assessment of sperm quality, testosterone, luteinizing hormone levels, and ox

SUBMITTER: Mahran Y 

PROVIDER: S-EPMC12217244 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature