Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.

ABSTRACT: Multidrug therapy for leprosy is highly effective and the recommended standard of care for leprosy worldwide. However, reports of antimicrobial resistance (AMR) have emerged globally. This study aimed to estimate the frequency of primary and secondary AMR associated with leprosy in patients treated at the Alfredo da Matta Foundation, Manaus, Amazonas, Brazil, as well as to determine the circulating subtypes of Mycobacterium leprae in this population. A total of 315 biopsy samples were investigated for variants in leprosy AMR-associated genes (rpoB, folP1, gyrA); a subset of 163 samples was also investigated for 5 additional candidate genes: gyrB, ctpC, ctpI, ribD, and fadD9. Patients were categorized into new cases, relapses, and suspected treatment failures. Fo

SUBMITTER: Ferrreira CdO 

PROVIDER: S-EPMC12217464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature