The Mechanism Exploration of Traditional Chinese Medicine's "Different Treatments for Same Disease" Concept in Osteoporosis Therapy: A Serum Metabolomics Study.

ABSTRACT: The "different treatments for same disease" is an important concept of traditional Chinese medicine (TCM) therapy. In TCM, osteoporosis (OP) treatment is aimed at invigorating blood, strengthening spleen, and tonifying kidneys, and their typical herbs are Angelica sinensis (Oliv.) Diels (Danggui, DG), Poria cocos (Schw.) Wolf (Fuling, FL), and Achyranthes bidentata Blume (Niuxi, NX). Nevertheless, molecular mechanisms of these different therapies of OP under the concept of "different treatments for same disease" are still unclear. The objective of this study was to identify the related metabolites and biological processes in these three distinct therapeutic approaches for osteoporosis, by using serum metabolomics analysis. A model of postmenopausal OP (PMOP) was created using bilateral ova

SUBMITTER: Wen J 

PROVIDER: S-EPMC12217658 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature