NHANES 2005-2018 data reveal high albumin-bilirubin scores are associated with depression.

ABSTRACT:

Background

Depression has been recognized as a leading global contributor to disease burden and mortality. While the etiology of depression involves a complex interplay of biological, psychological, and social factors, its precise pathophysiological mechanisms remain incompletely understood. The albumin-bilirubin (ALBI) score, originally developed as an objective measure of hepatic function, has demonstrated prognostic value in diverse clinical contexts including liver diseases, brain tumors and chronic heart failure. However, the relationship between ALBI scores and depression has not been systematically investigated. This study aims to examine the association between ALBI scores and depression in a nationally representative cohort.

Methods

This population-based cross-secti

SUBMITTER: Li QZ 

PROVIDER: S-EPMC12217803 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature