Whole-Genome Sequencing and Bioinformatics Analysis of ESBL- producing Klebsiella pneumoniae in a Ghanaian teaching hospital.

ABSTRACT:

Background

Multidrug-resistant (MDR) ESBL-producing K. pneumoniae is widely implicated in community and hospital-acquired infections. Thus, the current study determined the prevalence and clonal relatedness of MDR K. pneumoniae from hospital environments, patients and healthcare workers in a Ghanaian hospital.

Methods

Patients (rectal and hand, collected on admission and 48 h post admission), healthcare workers (hands) and hospital environment samples were sampled for three months. Antimicrobial susceptibility was determined using VITEK-2. Ten MDR ESBL-producing K. pneumoniae isolates were further analysed by whole-genome sequencing.

Results

All the isolates were ceftazidime-resistant; 90% were resistant to cefepime, amoxicillin/clavulanic, acid piperacillin/tazobacta

SUBMITTER: Asare Yeboah EE 

PROVIDER: S-EPMC12217819 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature