Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction.

ABSTRACT: Myocardial infarction (MI) is a life-threatening coronary artery-related pathology characterized by sudden cardiac death, often leading to cardiac fibrosis and heart failure (HF). Despite advances in emergency care and treatment measures such as percutaneous coronary intervention (PCI), the mortality rate due to HF following MI remains high, making it the leading cause of death in MI patients. While cardiac fibroblasts are known to be closely associated with the adverse outcomes of cardiac fibrosis and HF post-MI, the cellular landscape of fibroblasts after MI and their role in myocardial fibrosis and HF progression has not been fully explored. Our study identified a key, highly proliferative fibroblast subpopulation, named C1 Postn + Fibroblasts, which showed high myocardial fibrosis scor

SUBMITTER: Nie W 

PROVIDER: S-EPMC12217889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature