Robo1 CAR-NK92 and radiotherapy exert synergistic efficacy in solid tumors.

ABSTRACT:

Background

The efficacy of chimeric antigen receptor natural killer (CAR-NK) cells in treating solid tumors is often limited, primarily due to the tumor microenvironment (TME), which hinders the recognition and infiltration of CAR-NK cells. Radiotherapy has been shown to modify the TME, enhance immune cell infiltration, and improve the recognition of tumor cells by immune cells. This study aimed to investigate the effects of combining radiotherapy with CAR-NK cells in a solid tumor model.

Methods

The Robo1 CAR-NK92 cell line was developed to specifically target Robo1. Tumor cell lines were generated following radiotherapy, and the cytotoxicity and infiltration of Robo1 CAR-NK92 cells in solid tumor models were evaluated both in vitro and in vivo post-radiotherapy.

Results

SUBMITTER: Wu M 

PROVIDER: S-EPMC12218003 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature