Metformin and weight loss medication impact on survival outcomes in older women with obesity-related cancers.

ABSTRACT: While the association between metformin and mortality in obesity-related cancers (ORC: breast (BrCa), colorectal (CRC), endometrial (ECa), and ovarian (OCa)) remains inconsistent, the impact of weight loss medication (WLM) on mortality in ORC is largely unexplored, particularly among older women. This study aims to investigate the association between pre-diagnostic use of metformin and WLM with all-cause and cancer-specific mortality in older women with ORC. A retrospective cohort of 63,907 women (≥ 65 years) with ORC was identified using SEER-Medicare 2007-2015 data. Pre-diagnostic prescriptions of metformin and WLM were ascertained, and inverse probability of treatment weighting using propensity score (IPTW-PS) was utilized to balance baseline patient characteristics. Cox proportional ha

SUBMITTER: Hussain MR 

PROVIDER: S-EPMC12218299 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature