Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation.

ABSTRACT: Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling and transcriptional regulation that compromises hippocampal NSC activity during the early stage of chronological aging remains unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) on NSCs and newly generated neurons across different stages. Integrated data analysis revealed continuous alterations in the chromatin profile of hippocampal NSCs and their progeny from neonatal to mature adult stages, accompanied by consistent changes in transcriptional profiles. Further, decreased expression of Setd8, encoding the enzyme for histone H4 monome

SUBMITTER: Matsubara S 

PROVIDER: S-EPMC12218407 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature