Polymorphisms in SAA alter intrarenal amyloid distribution of AA amyloidosis in cats.

ABSTRACT: The kidneys are one of the primary organs affected by amyloid A (AA) amyloidosis in mixed-breed cats. The distribution of amyloid deposits within the kidneys varies among individuals; however, the underlying cause is unknown. This study investigated the association between serum AA (SAA) polymorphisms and the pattern of renal amyloid deposition in five mixed-breed cats. Histological analysis of the kidneys revealed amyloid deposits in the renal glomeruli and renal papillae in all cases. In contrast, the amyloid deposition pattern differed in the medulla, with widespread deposition from the corticomedullary junctional area to the inner medulla in two of the five cats. These amyloids were mainly located in the basement membrane of the renal tubules, extending towards the lumen and into the i

SUBMITTER: Kobayashi N 

PROVIDER: S-EPMC12218494 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature