<i>Streptococcus suis</i> serotype 5: Emerging zoonotic threat with distinct genomic heterogeneity.

ABSTRACT: Streptococcus suis is a significant pig pathogen and an emerging zoonotic agent. Serotype 5 is becoming an increasing concern among pigs and humans with S. suis infection worldwide. This study investigated the population structure, phylogenetic relationship, genomic characteristics, and virulence of serotype 5 population, analyzing 89 isolates, including eight from human cases. The results revealed significant genomic heterogeneity and diverse virulence levels within serotype 5 population. Phylogenetic analysis identified two distinct lineages with notable differences in evolution and genomic traits. Thirty-two representative serotype 5 strains were clustered into four groups: ultra-highly virulent (UV) (n = 1), highly virulent plus (HV⁺) (n = 4), HV

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12218517 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature