Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization.

ABSTRACT:

Background/aim

We conducted the Mendelian Randomization (MR) analysis to investigate the causal relationship between serum saturated fatty acids (SFAs) and the risk of heart stroke (HS).

Methods

The MRC-IEU Consortium provided summary statistics datasets related to SFAs, encompassing 64,979 individuals of European descent. Genetic variants associated with HF were identified using a GWAS dataset comprising 461,880 participants (cases = 7,055, controls = 454,825) of European descent from the UK Biobank. Generalized summary Mendelian Randomization (GSMR) assessed the potential association. Additionally, we performed a two-sample Mendelian Randomization (TSMR). The odds ratio (OR) with 95% confidence intervals (CIs) was indicated.

Results

The GSMR results suggested no sig

SUBMITTER: Habibi D 

PROVIDER: S-EPMC12218826 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature