Rate of de novo mutations in the three-spined stickleback.

ABSTRACT: As a fundamentally important genetic parameter and evolutionary force, germline mutation rates have many applications in evolutionary biology. However, accurate estimates of de novo mutation (DNM) rates are still relatively scarce, even for extensively studied evolutionary biology models. We estimated DNM rates for the three-spined stickleback (Gasterosteus aculeatus), the 'supermodel' of ecology and evolutionary biology. Using a large number of family trios sequenced to 45x coverage, we identified 115 unique mutations genome-wide and estimated the DNM rate at µ = 5.11 × 10^-9/bp/gen without any detectable sex bias. The localised DNM rate was found to be positively correlated with the recombination rate, supporting the notion that recombination is a mutagenic process. Correlation

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12218844 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature