Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects.

ABSTRACT: SHR8554 is a biased agonist for µ-opioid receptors, which was under investigation as an alternative therapy for clinical pain. This open, fixed-sequence study evaluated its pharmacokinetic (PK) interaction with itraconazole, a strong CYP3A4 inhibitor. Subjects (n = 16) were given SHR8554 (1 mg) intravenously on Day 1 and Day 9, and itraconazole capsules (200 mg) twice a day orally from Day 4 to Day 10. Liquid chromatography tandem mass spectrometry was applied for plasma concentration of SHR8554. After single dose of SHR8554, the C_max and T_max were 16.69 ± 3.48 ng/mL and 0.16 h, which was quite close to that of combination dose of itraconazole (C_max 16.58 ± 8.79 ng/mL, T_max 0.22 h). AUC_0-∞ under monotherapy (18.37 ± 3.61 ng∙h/mL) and c

SUBMITTER: Huang L 

PROVIDER: S-EPMC12218957 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature