Brain miR-137 governs growth and development via GH/IGF-1 signaling.

ABSTRACT:

Background

Brain-enriched miR-137 is highly associated with neuropsychiatric disorders and neural development. Although complete loss of miR-137 that leads to postnatal lethality had been addressed in mice, the underlying mechanism particularly related to growth and development remains unknown.

Results

MiR-137-deficient mice (Mir137^-/-) exhibited postnatal lethality, severe growth retardation, osteoporosis, fat atrophy, and hypothermia. Despite comparable serum growth hormone (GH) levels, IGF-1 levels in both liver and serum were significantly reduced, with compensatory upregulation of IGF-1 receptor expression in major organs. Reduced IGF-1 levels were not due to defects in GH secretion by the pituitary nor GH responsiveness of hepatocytes. Instead, impaired in v

SUBMITTER: Liao KM 

PROVIDER: S-EPMC12219031 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature