Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway.

ABSTRACT: Cerebral palsy (CP) is a complex neurological disorder characterized by motor and postural impairments, often stemming from prenatal or perinatal brain injury. Despite extensive research, the precise genetic mechanisms underlying CP remain elusive.Here, we employed genome-wide Summary-data based MR (SMR) and Mendelian randomization (MR) analysis to investigate the potential causal role of genes within the complement system in neuronal development and plasticity (CSNDP) pathway in CP pathogenesis. Leveraging summary-level data from large-scale GWAS and quantitative trait locus (QTL) studies, we assessed the associations of CSNDP-related gene expression, DNA methylation, and protein abundance with CP susceptibility.Our analysis identified several putatively causal genes associated with CP ri

SUBMITTER: Kun H 

PROVIDER: S-EPMC12219178 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature