TMBIM6 promotes glioma progression according to integrated bioinformatics and experimental evidence.

ABSTRACT: TMBIM6, a transmembrane BAX inhibitor motif containing 6, located in the endoplasmic reticulum, is linked to various cellular processes and cancer progression. Previous investigations showed a substantial association between TMBIM6 and survival in patients diagnosed with various cancer types. However, the lack of extensive studies addressing the correlation between TMBIM6 and gliomas necessitates a comprehensive investigation to explore its potential as a prognosis marker for glioma. This study investigates TMBIM6's prognostic value by using data from TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus), and CGGA (Chinese Glioma Genome Atlas) databases, along with histopathological analysis of tissue microarray slide. Survival analysis confirmed the prognostic significance of TMBI

SUBMITTER: Khatun MS 

PROVIDER: S-EPMC12219401 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature