Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.

ABSTRACT: Scaffold vascularization plays a pivotal role in the wound healing process, facilitating the recruitment of endogenous progenitor cells and delivering crucial signaling molecules that promote cellular invasion, angiogenesis, and neotissue formation. In this study, we introduce nanosilicates as proangiogenic biomaterials that can prime endogenous cells to expedite angiogenesis and graft vascularization in vivo. Characterized by their mineral-based two-dimensional structure and extensive surface area, nanosilicates are efficiently internalized by endothelial cells, leading to augmented cellular migration and the formation of tubular structures. Through whole transcriptome sequencing, we elucidated that nanosilicates activate the canonical Wnt pathway through hypoxia-induced ROS production. I

SUBMITTER: Lokhande G 

PROVIDER: S-EPMC12219486 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature