Gluconeogenesis related gene signatures as biomarkers for nonspecific orbital inflammation.

ABSTRACT: Nonspecific orbital inflammation (NSOI) is a chronic, idiopathic inflammatory disorder marked by persistent tissue proliferation and immune activation. Gluconeogenesis, a core metabolic pathway enabling endogenous glucose production in the absence of dietary input, plays a vital role in cellular energy homeostasis and immune regulation. Metabolic rewiring of immune cells is not merely a consequence of inflammation but a critical determinant of disease trajectory in orbital disorders. Within this conceptual landscape, the exploration of gluconeogenesis represents a logical and timely extension, offering potential insights into how alternative metabolic pathways may orchestrate immune cell function and fibrotic responses in the orbital microenvironment. Differentially expressed genes (DEGs)

SUBMITTER: Dong B 

PROVIDER: S-EPMC12219558 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature