Berberine chloride hydrate impairs Streptococcus mutans biofilm formation via inhibiting sortase A activity.

ABSTRACT: Dental caries is a biofilm-associated chronic progressive disease, results from the dissolution of mineralized tooth tissue by acidic generated from bacterial sugar fermentation. S. mutans, a prominent pathogen of dental caries, is acknowledged for its role in cariogenic biofilm formation, utilizing Sortase A (SrtA) to catalyse surface proteins, thus promoting biofilm formation. In our previous studies, the inhibitory effect of the berberine chloride hydrate (BH) on S. mutans biofilms was confirmed. Here, we further investigate the influence of BH on S. mutans biofilm-induced bovine enamel caries model and explore the effect of BH on S. mutans SrtA activity. We found that BH inhibited S. mutans biofilm formation in bovine enamel model, leading to a reduction in demineralization. Furthermor

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12219681 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature