Impact of antihypertensive drug classes on cardiovascular outcomes: insights from the STEP study.

ABSTRACT:

Background

The optimal class of antihypertensive drugs for reducing cardiovascular risk remains unclear. This study investigated whether prolonged exposure to specific antihypertensive drug classes is associated with lower cardiovascular risk in individuals with well-controlled blood pressure.

Methods

This study utilised data from the STEP trial, which enrolled elderly, hypertensive Chinese patients with no history of stroke. After excluding 234 patients lost to follow-up and 20 patients without blood pressure records after randomisation, 8257 patients were included. The relative time on each antihypertensive drug (medication time/event time) was calculated. The primary outcome was a composite of the first occurrence of stroke, acute coronary syndrome (ACS), acute decompensa

SUBMITTER: Peng X 

PROVIDER: S-EPMC12219695 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature