Multidimensional pan-cancer analysis reveals the impact of PPIA on tumor epigenetic modifications and immune regulation.

ABSTRACT: Peptidylprolyl isomerase A (PPIA) is a key molecule involved in various biological functions and has been implicated in multiple diseases. However, the biological significance of PPIA in pan-cancer remains unclear. We assessed the pan-cancer expression, prognostic value, and biological functions of PPIA through multiple databases and multidimensional analysis. We also investigated the correlation of PPIA with the immune microenvironment, epigenetic modifications, and drug sensitivity. Expression validation was performed using Western Blot (WB) and quantitative PCR (qPCR). PPIA was found to be highly expressed in most cancers and identified as a prognostic risk factor. The expression of PPIA in most cancers showed significant correlations with immune cell infiltration, major histocompatibil

SUBMITTER: Yao Y 

PROVIDER: S-EPMC12219773 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature