Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells.

ABSTRACT: Embryo development is highly susceptible to environmental stressors, contributing significantly to early miscarriages in 70% of human embryos (Cross et al. in Science 266:1508-1518, 1994, Macklon et al. in Hum Reprod Update 8:333-343, 2002). Yet the underlying mechanisms remain poorly understood. Here, we employ mouse embryonic stem cells (ESC) as a model to identify shared "pan-stress" markers for responses to diverse environmental insults implicated in miscarriage (Puscheck et al. in Birth Defects Res 114:1014-1036, 2022, Puscheck et al., in: Leese HJ, Brison DR (eds) Cell Signaling During Mammalian Early Embryo Development, Springer, New York, 2015 ). ESC were exposed to control stimuli and diverse stressors at previously characterized risk levels for growth, mimicking miscarriage risk

SUBMITTER: Singh A 

PROVIDER: S-EPMC12219851 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature