Association of miR-938 rs2505901 T > C polymorphism with reduced risk of venous malformations in a Chinese population.

ABSTRACT: Venous malformations are a common congenital vascular disorder. MicroRNAs are micro non-coding RNAs that are responsible for regulating the expression of genes after transcription. This study aimed to investigate the relationship between miR-938 rs2505901 T > C polymorphism and venous malformations. We collected blood samples from 1,113 patients with venous malformations and 1,158 members of the control group. TaqMan genotyping of miR-938 rs2505901 T > C was performed by real-time fluorescence quantitative polymerase chain reaction. We found the miR-938 rs2505901 T > C polymorphism was significantly associated with reduced risk of venous malformations in children [CC vs. TT: adjusted OR = 0.56, 95% confidence interval (CI) = 0.33-0.94, P = 0.027; CC vs. TT/TC: adjusted OR = 0.56, 95% CI = 

SUBMITTER: Xie S 

PROVIDER: S-EPMC12219894 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature