Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4/PPARG pathway.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) remains the deadliest subtype of breast cancer owing to high metastatic potential and poor prognosis. Herein, we examined the antitumor effects of ursolic acid (UA), a pentacyclic triterpene compound, against TNBC and the underlying mechanisms.

Methods

TNBC cells were exposed to a graded concentration of UA, and cell proliferation and migration were examined through CCK-8 and wound healing assays. Transcriptome data of 116 TNBC and 290 normal tissues were acquired for determining differentially expressed genes. Using the PubChem and the SwissTargetPrediction, potential UA targets were inferred. 10 pairs of human TNBC and normal tissues were gathered for examining the expression of UA targets FABP4 and PPARG. The influence of FA

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12219972 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature