Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals.

ABSTRACT:

Background

The gut microbiome is crucial for human health maintenance and disease development, yet limited understanding of its structure and maintenance hinders effective microbiome-based health improvement strategies. We investigated gut microbiome compositional patterns in healthy Koreans (n = 890), identifying six clusters (I-VI) with unique compositions and host preferences.

Results

Each cluster had a distinct topological structure within the microbial interaction network, underscoring its diverse roles in maintaining microbial communities. Cluster II, predominated by Bacteroides and Faecalibacterium, was consistently found across individuals and centrally located within the microbial interaction network. Cluster III, mainly composed of Oscillospira and Coprococcus, and

SUBMITTER: Hong S 

PROVIDER: S-EPMC12220063 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature