Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline.

ABSTRACT:

Background

Alzheimer disease (AD) clinical progression is highly heterogeneous, making its prediction essential for the development of effective therapies. The advancement of cognitive decline in AD is tightly linked to the spread of pathological tau protein aggregates in the brain, through tau seeding properties.

Methods

We developed a cellular biosensor to measure tau seeding activity from cerebrospinal fluid (CSF) and human brain lysates. Longitudinal analysis of cognitive function was correlated with biosensor response.

Results

Individuals with CSF exhibiting high or intermediate seeding activity experienced more rapid cognitive decline compared to those with low seeding. High tau seeding was associated with total and phosphorylated tau biomarkers in AD. The biose

SUBMITTER: Houze L 

PROVIDER: S-EPMC12220128 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature