T-RNA mediates provirus deletion in HIV-infected cells.

ABSTRACT:

Background

In the early phase of HIV infection, as studied in vitro, high levels of unintegrated (both linear and circular) and integrated (provirus) forms of viral DNA are seen, and cells produce high levels of virus. In time, the level of unintegrated DNA declines, followed by a progressive decline in virus expression. Extensive studies of the proviral landscape in people living with HIV (PLWH) on antiretroviral therapy (ART) show that only about 2% of proviruses are intact; the remainder are characterized as defective and contain numerous deletions of proviral DNA segments and hypermutations. In the current study, we investigated the decline of viral expression in infected T cells in search of mechanisms involved in proviral inactivation.

Results

We derived clonal lines f

SUBMITTER: Gurgo C 

PROVIDER: S-EPMC12220202 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature