Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids.

ABSTRACT:

Background

3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes.

Methods

We collected data from three multicenter prospective studies to evaluate the ability to establish Patient-Derived Organoids (PDOs) from different biological samples and timepoints, correlating their characteristics and drug sensitivity with clinical outcomes.

Results

From 184 patients (17 tumor types), 249 samples were collected: 149 (59.8%) from tumor tissue, 61 (24.5%) from peritoneal fluids, 39 (15.7%) from peripheral blood. Success rates for PDO establishment were 39.5%, 34.4%, and 25.6%, respectively. PDOs reproduced pathological and immunohistochemical patterns of source tumors, with pathogen

SUBMITTER: Navarro P 

PROVIDER: S-EPMC12220348 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature