Exploring the shared genetic architecture between testosterone traits and major depressive disorder.

ABSTRACT:

Background

The association between major depressive disorder (MDD) and testosterone levels is controversial, and whether they are genetically correlated remains unclear. The present study aimed to investigate the shared genetic architecture between MDD and three testosterone traits.

Methods

We acquired genetic datasets of MDD and testosterone traits from publicly available genome-wide association studies. The bivariate causal mixture modeling (MiXeR) method was applied to estimate the polygenic overlap between MDD and testosterone, and the conjunctional false discovery rate (conjFDR) tool was used to identify shared genomic loci.

Results

Analysis with MiXeR suggested total testosterone (TT) and sex hormone-binding globulin (SHBG) were negative correlated with MDD, whi

SUBMITTER: Lu W 

PROVIDER: S-EPMC12220508 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature