Subtractive proteo-genomics and model-based druggability analyses prioritized nitrate reductase-A subunit-α as potential therapeutic target against MDR pneumonia; a homology-based approach.

ABSTRACT:

Background

Bacterial pneumonia is a severe respiratory infection that damages the lungs, representing one of the most serious public health problems worldwide due to its morbidity and mortality across all age groups. The challenge is further exacerbated by emergence of multidrug-resistant strains of Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, and Haemophilus influenzae, making pneumonia treatment increasingly difficult due to the persistent spread of antimicrobial resistance. Consequently, it is crucial to explore novel therapeutic targets to treat multidrug-resistant pneumonia.

Results

The current study is based on comprehensive analyses of proteo-genomics data from multidrug-resistant leading pneumonia pathogens. Its aim is to identify promising

SUBMITTER: Begum K 

PROVIDER: S-EPMC12220599 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature