Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance.

ABSTRACT:

Background

In our previous research, we identified five candidate proteins-Carbonic Anhydrase 1 (CA-1), Matrix Metallopeptidase 9 (MMP9), Peroxiredoxin 2 (PRDX2), Phenylalanyl-tRNA Synthetase Subunit Beta (FARSB), and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)-as prospective biomarkers for bipolar II disorder (BD-II). In this study, we explored the relationships between these potential plasma proteins and cognitive performance in BD-II patients using the Brief Assessment of Cognition in Affective Disorders (BACA), a validated tool for assessing cognitive deficits in mood disorders.

Methods

One hundred and seventeen participants with BD-II and 41 controls participated in this study. Plasma concentrations of the aforementioned proteins were measured, and cognitive p

SUBMITTER: Lee SY 

PROVIDER: S-EPMC12220648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature