The N6-methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant RNA modification in mammalian cells, and has emerged as an important player in tumour development through post-transcriptional gene regulation. In this study, we found that the m⁶A reader protein IGF2BP3 was the most upregulated m⁶A modifier in bladder cancer through the proteomic analysis of 17 pairs of human bladder cancer tissues and adjacent normal bladder tissues, for which the expression was also positively correlated with higher tumour stage and poorer prognosis. In vitro and in vivo assays demonstrated the powerful oncogenic function of IGF2BP3 in bladder cancer. Further combined analyses of RNA-sequencing, m⁶A-sequencing, and RIP (RNA Binding Protein Immunoprecipitation)-sequencing

SUBMITTER: Chen X 

PROVIDER: S-EPMC12220844 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature