The distal nephron biomarkers associate with diabetic kidney disease progression.

ABSTRACT: BACKGROUNDWhile urinary biomarkers show promise in predicting diabetic kidney disease (DKD) progression, distal tubular markers remain understudied. We investigated the association of distal tubule markers, epidermal growth factor (EGF) and uromodulin (UMOD), with DKD progression in the Veterans Affairs Diabetes in Nephropathy (VA NEPHRON-D) clinical trial.

Methods

We used Cox regression models to evaluate the association between each biomarker and DKD progression and the relationship between change over time in biomarker and DKD progression. We used mixed models to investigate biomarker levels at baseline, 12 months, and over time and their relationships with longitudinal eGFR change.

Results

Participants (n = 1,116) had type 2 diabetes, urine albumin-to-creatinine ratio (UA

SUBMITTER: Tamargo CL 

PROVIDER: S-EPMC12220953 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature