TIAM1 drives prostatic branching phenotype and is a potential therapeutic target for benign prostatic hyperplasia.

ABSTRACT: Benign prostatic hyperplasia (BPH) is the most common urologic condition in elderly men, characterized by the reactivation of developmental programs such as prostatic budding and branching. However, the molecular mechanisms underlying this reactivation in BPH remain unclear. In this study, we identified T-lymphoma invasion and metastasis-inducing protein-1 (TIAM1) as a critical regulator of prostatic budding and branching. By generating an unbiased BPH transcriptomic signature from patient datasets, we discovered an upregulation of TIAM1, which was subsequently validated at the protein level. Functional assays using organoid cultures derived from human prostatic cell lines revealed that TIAM1 is essential for prostatic budding and branching. Additionally, the BPH transcriptomic signature i

SUBMITTER: Khedmatgozar H 

PROVIDER: S-EPMC12220968 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature