Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study.

ABSTRACT:

Background

Minimum alveolar concentration (MAC) is a standard dosing metric for general anesthesia. Although influences of MAC have been identified in controlled studies, the determinants of clinical delivery of MAC ratio are largely unknown. To address this knowledge gap, the authors performed this single-center retrospective study. The primary objective was to understand factors associated with MAC ratio, as indexed by the end-tidal volatile anesthetic concentration, for a given case. It was hypothesized that mean arterial pressure (MAP) was strongly associated with anesthetic delivery; a secondary objective was to perform a genome-wide association study to identify genetic variants associated with MAC ratio in clinical practice.

Methods

The primary outcome was mean age-ad

SUBMITTER: Douville NJ 

PROVIDER: S-EPMC12221193 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature