Temporal Wheat Proteome Remodeling by Deoxynivalenol Reveals Novel Detoxification Signatures and Strategies Across Cultivars.

ABSTRACT: Fusarium head blight (FHB) is a globally devastating fungal disease resulting in reduced grain yield and quality, along with contamination of grains with dangerous mycotoxins. Consumption of such mycotoxins through processed food or livestock feed has downstream implications for human and animal health. This interconnectivity across the environment, animal, and human health defines the One Health problem of threatened food safety and security. In this study, we explore remodeling of the wheat proteome upon exposure to a common mycotoxin, deoxynivalenol (DON). We investigate cultivar-specific responses to DON exposure in FHB-susceptible (Norwell) and -resistant (Sumai#3) cultivars across a continuum of exposure (i.e., 24 and 120 h post inoculation) and upon low (i.e., 0.1 mg/ml) and high (1

SUBMITTER: Buchanan R 

PROVIDER: S-EPMC12221369 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature