Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study.

ABSTRACT:

Background

Previous studies have identified correlations between autoimmune and aortic diseases; however, the causal connection between these conditions remains uncertain and lack of comprehensiveness. This study aimed to investigate the potential causal relationships between autoimmune and aortic diseases from a genetic perspective.

Methods

A two-sample Mendelian randomization (MR) study was implemented to investigate the relationships between 17 common autoimmune diseases and aortic diseases. To serve as instrumental variables (IVs), we extracted single-nucleotide polymorphisms from both the genome-wide association study and the FinnGen databases. The inverse-variance weighted (IVW) approach was primarily employed to estimate causal links between autoimmune and aortic dise

SUBMITTER: Chen D 

PROVIDER: S-EPMC12221440 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature