Curcumin alleviates proliferation dysfunction in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway.

ABSTRACT: High concentrations of reactive oxygen species (ROS) induce oxidative harm in laying chickens, leading to a drop in egg production efficiency. Curcumin alleviates oxidative stress-induced dysfunction by eliminating excess ROS. To investigate the underlying molecular mechanisms, we simulated oxidative stress and antioxidant processes in primary chicken granulosa cells. The results demonstrated that oxidative stress induced proliferation dysfunction in chicken granulosa cells, while curcumin treatment restored normal cell proliferation. Transcriptome sequencing identified a set of key genes. Among them, MHCY14, WFIKKN1, STARD10, and POU3F3 were significantly upregulated under oxidative stress and significantly downregulated during the antioxidant process. In contrast, TMEM45L, GH, C10orf71,

SUBMITTER: Yu S 

PROVIDER: S-EPMC12221450 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature