Exploration of pharmacological potentialities of Bauhinia acuminata L. fruits by in vitro and in vivo assays supported by computational analysis.

ABSTRACT:

Background

In Ayurveda, Bauhinia acuminata L. had been used to treat diabetes, skin diseases, and swelling.

Objective

The study was designed to assess the antidiabetic, anti-inflammatory, and antibacterial potentialities of B. acuminata fruits ethanolic extract. Phytochemical characterization by HPLC analysis, pure compound isolation by column chromatography and in silico analysis were performed.

Methods

Column chromatography was conducted to isolate pure compounds. HPLC analysis was performed using sixteen standard polyphenol s. Three different methods evaluated the antidiabetic effect of the extract. Analgesic property was evaluated. Protein denaturation and formalin-induction tests were done to measure the anti-inflammatory effect. Brewer's yeast-induced pyrexia wa

SUBMITTER: Sikdar P 

PROVIDER: S-EPMC12221455 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature