Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis.

ABSTRACT: The circadian clock regulates tissue-specific homeostasis, and its disruption is associated with metabolic disorders. Both host metabolic processes and the gut microbiota exhibit diurnal regulation, and both contribute to the maintenance of glucose homeostasis (Thaiss et al., 2014; Bishehsari et al., 2020; Frazier et al., 2023) [1-3]. However, how the gut microbiota and the circadian rhythm interplay to control host glucose homeostasis is not fully understood. Here, we identified gut microbiota-derived extracellular vesicles (MEV) as a potential peripheral Zeitgeber (time cue) for the hepatic circadian clock, controlling hepatic gluconeogenesis. Host feeding patterns influence the gut microbiota, driving the diurnal production of MEV. Gut MEV levels coincide with the activity of hepatic gl

SUBMITTER: Tan J 

PROVIDER: S-EPMC12221565 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature