Effect of Life Course Adiposity on Bell's Palsy Mediated by Glucose Levels.

ABSTRACT:

Introduction and aims

Previous observational studies have reported an association between obesity and Bell's palsy (BP), but the causality and the underlying mediating pathways remain unclear. We aimed to investigate the causal effects of adiposity across the life course on BP and to identify potential mediators in this relationship.

Methods

Utilizing summary statistics from genome-wide association studies predominantly of European ancestry, we conducted univariable and multivariable Mendelian randomization (MR) to estimate overall and independent effects of 5 adiposity-related traits (birth weight, childhood body mass index [BMI], adult BMI, adult body fat percentage, and adult waist circumference) on BP. Two-step MR was employed to assess the mediating role of metabolic an

SUBMITTER: Chen X 

PROVIDER: S-EPMC12221623 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature