Structural and functional insights into Listeriamonocytogenes phage endolysin PlyP100: A promising food safety tool.

ABSTRACT: Listeria monocytogenes is a ubiquitous, psychrotrophic human pathogen that can cause listeriosis, a serious illness for vulnerable populations. Some foods, such as Hispanic-style fresh cheeses like queso fresco, pose a specific risk because there are no widely accepted or available methods for L. monocytogenes mitigation that are both effective and able to maintain the properties of the products. Listeria-specific bacteriophages encode endolysins that can cleave the peptidoglycan layer of L. monocytogenes cells externally, showing promise as a potential solution to this problem. PlyP100, from the GRAS Listeria phage P100, is one such endolysin that can prevent the growth of L. monocytogenes in both lab culture conditions and a miniaturized queso fresco model. In this work, we aimed to unde

SUBMITTER: Bateman KR 

PROVIDER: S-EPMC12221725 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature