Light-Controlled Intracellular Synthesis of Poly(luciferin) Polymers Induces Cell Paraptosis.

ABSTRACT: Accumulation of misfolded proteins challenges cellular proteostasis and is implicated in aging and chronic disorders. Cancer cells, moreover, face an elevated level of basal proteotoxic stress; hence, exacerbating endoplasmic reticulum (ER) stress has been shown to induce programmed cell death while enhancing anticancer immunogenicity. We hypothesize that hydrophobic abiotic macromolecules can trigger a similar stress response. Most polymers and nanoparticles, however, are sequestered in endo/lysosomes after endocytosis, which prevents their interaction with the proteostasis machinery. We adopted an in situ polymerization approach to synthesize polymers in cells with cell-permeable monomers. Specifically, we developed a biocompatible polycondensation between l-cysteine and 2-cyanobe

SUBMITTER: Dai SY 

PROVIDER: S-EPMC12221825 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature