Delayed surgery for more than 9 weeks induces worse survival outcomes in locally advanced rectal cancer patients with poor response to neoadjuvant chemoradiotherapy: a propensity score matched cohort study.

ABSTRACT:

Background

The association between delayed surgery and survival outcomes in locally advanced rectal cancer patients with a poor response to neoadjuvant chemoradiotherapy (nCRT) remains unclear. This study aimed to determine the optimal timing of surgery following nCRT in these patients and to explore the association between delayed surgery and survival outcomes.

Methods

Restricted cubic spline curves were used to determine the optimal timing of surgery for patients with a poor response to nCRT (ypT2-4N0 or ypTxN+). The patients were divided into two groups: the early surgery group and the delayed surgery group. Propensity score matching (PSM) analysis was employed to reduce the selection bias and survival analysis was conducted to assess the survival differences. Immunostain

SUBMITTER: Wang H 

PROVIDER: S-EPMC12221869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature