A splice donor variant in <i>SLAMF1</i> is associated with canine atopic dermatitis.

ABSTRACT:

Introduction

Canine atopic dermatitis (CAD) is a common inflammatory skin condition in dogs. It is a lifelong issue that poses a significant welfare concern due to the chronic skin discomfort and pruritus (itching) experienced by affected animals. Excessive scratching, licking, and chewing cause self-inflicted injuries to the skin and increase the risk of secondary infections. Several dog breeds, including Labrador Retriever, Boxer, and French Bulldog, are known to be predisposed to these issues, suggesting a genetic link to the condition.

Methods

Access to a large population of dogs genotyped on a medium-density single-nucleotide polymorphism (SNP) array through commercial Wisdom Panel testing, along with their linked clinical records, allowed a large-scale, highly powered

SUBMITTER: Forman OP 

PROVIDER: S-EPMC12221898 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature