Age associated SARS-CoV-2 immune responses provide insights into population immunity over four years since the COVID-19 pandemic.

ABSTRACT: As SARS-CoV-2 variants continue to emerge, the extent of their impact on shaping population immunity through repeated waves remains poorly understood. This study assessed age-specific immune responses and the effects of vaccination on neutralization against wild-type (WT) and JN.1 variants. We analyzed 4,371 serum samples from individuals aged 6 months-80 years (May-August 2024). We found that 95.1% of participants had detectable anti-N Ig, suggesting widespread prior infection. Among unvaccinated children (6 months-4 years), 96.5% exhibited anti-RBD or anti-N Ig antibodies mostly from asymptomatic infections. Neutralization against JN.1 did not significantly differ by age, but children aged 6 months-4 years exhibited higher JN.1 neutralization than WT, while individuals aged ≥ 12 years sh

SUBMITTER: Suntronwong N 

PROVIDER: S-EPMC12222500 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature