Fagonia indica extract encapsulated in PLGA nanocarriers demonstrated enhanced therapeutic efficacy through improved intracellular uptake of photoactive metabolites.

ABSTRACT: Fagonia indica (FI), a member of the Zygophyllaceae family, is known for its medicinally important components, such as glycosides, saponins, flavonoids, phenols, and alkaloids. The complex mixture of phytochemicals in the extract limits its aqueous solubility and bioavailability, resulting in low therapeutic outcomes. We aim to enhance the bioavailability of FI extract by encapsulating it into Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (FI-PLGA NPs) and evaluate its cytotoxicity and phototoxicity against the BT-474 cell line. FI-PLGA NPs were prepared via a single emulsion solvent evaporation method. The optical properties, structural analysis, and hydrodynamic size of the synthesized NPs were characterised by UV-Visible spectroscopy, fluorescence spectroscopy, Fourier transform i

SUBMITTER: Naz S 

PROVIDER: S-EPMC12222523 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature