Analysis of femoroacetabular impingement by a triade of label-free optical spectroscopy techniques.

ABSTRACT: Understanding the biochemical mechanisms of hip joint diseases remains challenging. Femoroacetabular impingement (FAI) is a condition where developmental deformities of the hip joint reduce mobility and cause tissue damage, with characteristic red staining observed in affected cartilage. Here we show how combining three complementary optical analysis techniques- laser-induced breakdown spectroscopy, Raman spectroscopy, and diffuse reflectance spectroscopy- reveals tissue alterations without invasive procedures. Our analysis identifies elevated amide I levels indicating bone damage, reduced hydroxypyroline showing active bone regeneration, and increased mineral components (phosphate and carbonate) reflecting bone hardening. These bone healing processes elevate tyrosine levels in the affecte

SUBMITTER: Hohmann M 

PROVIDER: S-EPMC12222648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature