Preservation of bronchial artery circulation on ex-vivo lung perfusion.

ABSTRACT: Lungs receive blood supply from the pulmonary and bronchial arteries. After transplantation, lungs uniquely suffer from ischemia and injury to the airways, in part due to the surgical sacrifice of the bronchial artery circulation during procurement and implantation. Ex-vivo lung perfusion (EVLP) offers a platform to rehabilitate and assess donor lungs; however, it traditionally excludes bronchial circulation. We hypothesized that bronchial artery perfusion during EVLP may enhance airway preservation. A dual-circulation EVLP platform was developed using swine donor lungs with preserved bronchial arteries. Blood was separately routed to the pulmonary artery and to the bronchial arteries. Laser speckle contrast imaging (LASCA) was performed pre- and post-initiation of bronchial perfusion, and

SUBMITTER: Krishnan A 

PROVIDER: S-EPMC12222659 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature